Peripheral Skeletal Muscle Alterations in Adults Born Preterm: An Observational Comparative Study

Deprez, A.; El-Jalbout, R.; Cloutier, A.; Gagnon, D.; Gagnon Hamelin, A.; Mathieu, M.-E.; Arabi Kugathasan, T.; Dumont, N.; Nuyt, A. M.; Luu, T. M.

doi:10.1101/2024.07.08.602584

bioRxiv · 10.1101/2024.07.08.602584

Peripheral Skeletal Muscle Alterations in Adults Born Preterm: An Observational Comparative Study

Deprez, A.·El-Jalbout, R.·Cloutier, A.·Gagnon, D.·Gagnon Hamelin, A.·Mathieu, M.-E.·Arabi Kugathasan, T.·Dumont, N.·Nuyt, A. M.·Luu, T. M.

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Abstract

Prematurity is associated with reduced exercise capacity, which relies on the integrity of the cardiovascular, pulmonary, and skeletal muscle systems. Our animal model mimicking prematurity-associated conditions showed altered muscle composition and atrophy in adulthood. This study aimed to compare muscle composition and strength in adults born preterm versus full-term controls. This observational cohort study recruited 55 adults born preterm, [≤]29 weeks of gestation and 53 full-term controls who underwent musculoskeletal ultrasound imaging to assess morphology of the rectus femoris at rest and during a maximal voluntary contraction. Maximal voluntary contraction of the hands and legs were measured by manual dynamometry. In adults born preterm, there was a reduction in muscle strength (handgrip: -4.8 kg, 95% CI -9.1, -0.6; knee extensor: -44.6 N/m, 95% CI -63.4, -25.8) and muscle area (-130 mm2, 95% CI -207, -53), which was more pronounced with a history of bronchopulmonary dysplasia. Muscle stiffness was increased in the preterm group (0.4 m/s, 95% CI 0.04, 0.7). Prematurity is associated with alterations in skeletal muscle composition, area, and function in adulthood. These findings highlight the necessity to implement preventive and/or curative approaches to improve muscle development and function following preterm birth to enhance overall health in this population. Whats known on This SubjectPreterm birth is associated with reduced exercise capacity. However, the impact of preterm birth on skeletal muscle, a critical player of exercise capacity, in adulthood remains unclear. What This Study AddsOur findings provide novel insights into the potential long-term effects of preterm birth and the contributions of bronchopulmonary dysplasia on peripheral muscle-related health outcomes, such as muscle composition (reduced muscle area and increased muscle stiffness) and function (reduced muscle strength).

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Deprez, A., El-Jalbout, R., Cloutier, A., Gagnon, D., Gagnon Hamelin, A., Mathieu, M.-E., Arabi Kugathasan, T., Dumont, N., Nuyt, A. M., Luu, T. M.. 2024-07-11. Peripheral Skeletal Muscle Alterations in Adults Born Preterm: An Observational Comparative Study. https://doi.org/10.1101/2024.07.08.602584

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