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bioRxiv · 10.1101/2024.07.02.601775

Biochemical implementation of acceleration sensing and PIDA control

Alexis, E.·Espinel-Rios, S.·Kevrekidis, I. G.·Avalos, J. L.
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Abstract

Designing dependable, self-regulated biochemical systems has long posed a challenge in the field of Synthetic Biology. Here, we propose a realization of a Proportional-Integral-Derivative-Acceleration (PIDA) control scheme as a Chemical Reaction Network (CRN) governed by mass action kinetics. A constituent element of this architecture is a speed and acceleration biosensing mechanism we introduce and, subsequently, place within a feedback configuration. Our control scheme provides enhanced dynamic performance and robust steady-state tracking. In addition to our theoretical analysis, this is practically highlighted in both the deterministic and stochastic settings by regulating a specific biochemical process in-silico and drawing comparisons with a simpler PID controller.

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Alexis, E., Espinel-Rios, S., Kevrekidis, I. G., Avalos, J. L.. 2024-07-02. Biochemical implementation of acceleration sensing and PIDA control. https://doi.org/10.1101/2024.07.02.601775

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