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bioRxiv · 10.1101/2024.06.17.599464

Spatial Transcriptomics Prediction from Histology Images at Single-cell Resolution using RedeHist

Zhong, Y.·Zhang, J.·Ren, X.
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Abstract

Spatial transcriptomics (ST) offers substantial promise in elucidating the tissue architecture of biological systems. However, its utility is frequently hindered by constraints such as high costs, time-intensive procedures, and incomplete gene readout. Here we introduce RedeHist, a novel deep learning approach integrating scRNA-seq data to predict ST from histology images at single-cell resolution. Application of RedeHist to both sequencing-based and imaging-based ST data demonstrated its outperformance in high-resolution and accurate prediction, whole-transcriptome gene imputation, and fine-grained cell annotation compared with the state-of-the-art algorithms.

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Zhong, Y., Zhang, J., Ren, X.. 2024-06-22. Spatial Transcriptomics Prediction from Histology Images at Single-cell Resolution using RedeHist. https://doi.org/10.1101/2024.06.17.599464

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