Prevalent chromosome fusion in Vibrio cholerae O1

Cuenod, A.; Chac, D.; Khan, A. I.; Chowdhury, F.; Hyppa, R. W.; Markiewicz, S. M.; Calderwood, S. B.; Ryan, E. T.; Harris, J. B.; LaRocque, R. C.; Bhuiyan, T. R.; Smith, G. R.; Qadri, F.; Lypaczewski, P.; Weil, A. A.; Shapiro, B. J.

doi:10.1101/2024.06.12.598706

bioRxiv · 10.1101/2024.06.12.598706

Prevalent chromosome fusion in Vibrio cholerae O1

Cuenod, A.·Chac, D.·Khan, A. I.·Chowdhury, F.·Hyppa, R. W.·Markiewicz, S. M.·Calderwood, S. B.·Ryan, E. T.·Harris, J. B.·LaRocque, R. C.·Bhuiyan, T. R.·Smith, G. R.·Qadri, F.·Lypaczewski, P.·Weil, A. A.·Shapiro, B. J.

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Abstract

Two circular chromosomes are a defining feature of the family Vibrionaceae, including the pathogen Vibrio cholerae, with rare reports of isolates with a single, fused chromosome. Here we report chromosome fusions in clinical V. cholerae O1 isolates, including several independent fusion events stable enough to be transmitted between patients within a household. Fusion occurs in a 12 kilobase-pair homologous sequence shared between the two chromosomes, which may lead to reversible chromosomal fusion.

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Cuenod, A., Chac, D., Khan, A. I., Chowdhury, F., Hyppa, R. W., Markiewicz, S. M., Calderwood, S. B., Ryan, E. T., Harris, J. B., LaRocque, R. C., Bhuiyan, T. R., Smith, G. R., Qadri, F., Lypaczewski, P., Weil, A. A., Shapiro, B. J.. 2024-06-12. Prevalent chromosome fusion in Vibrio cholerae O1. https://doi.org/10.1101/2024.06.12.598706

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