Interactively Integrating Reach and Grasp Information in Macaque Premotor Cortex

Abstract

Successful reach-to-grasp movements necessitate the integration of both object location and grip type information. However, how these two types of information are encoded in a single brain region and to what extend they interact with each other, remain largely unknown. We designed a novel experimental paradigm that sequentially prompted reach and grasp cues to monkeys and recorded neural activity in the dorsal premotor cortex (PMd) to investigate how the encoding structures change and interact during arm reaching and hand grasping movements. This paradigm required monkeys to retain the first prompted cue when the second one arrived, and integrate both to accomplish a final goal movement. PMd neurons represented both reach and grasp to similar extend, yet the encodings were not independent. Upon the arrival of second cue, PMd continued to encode the first cue, albeit with a significantly altered structure, as evidenced by more than half of the neurons displaying incongruent modulation. At a population level, the encoding structure formed a distinct subspace that differed from, but was not entirely orthogonal to, the original one. Employing canonical correlation analysis, we identified a subspace that consistently preserved the encoding of the initial cue, potentially serving as a mechanism for downstream brain regions to extract coherent information. Furthermore, this shared subspace comprised a diverse population of neurons, including both congruent and incongruent units. these findings support the argument that reach and grasp information are interactively integrated within PMd, with a shared subspace likely underpinning a consistent encoding framework.