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bioRxiv · 10.1101/2024.06.07.597902

Impact of life origins on metabolism

Vazquez, A.
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Abstract

Living organisms are defined by self-replication and self-confinement. We expect these two properties to shape the metabolic capabilities of cells. Here I demonstrate that the maximum growth rate of cells is, in a first approximation, the geometric mean between the maximum rate of ribosome self-replication and the maximum rate of macromolecular synthesis allowed by the interior volume defined by the cell membrane. I also show how these constraints are buried into the biomass compositions of flux balance models.

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Vazquez, A.. 2024-06-18. Impact of life origins on metabolism. https://doi.org/10.1101/2024.06.07.597902

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