Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy

Valentino, T. R.; Burke, B. I.; Kang, G.; Goh, J.; Dungan, C. M.; Ismaeel, A.; Mobley, C. B.; Flythe, M. D.; Wen, Y.; McCarthy, J. J.

doi:10.1101/2024.05.29.596432

bioRxiv · 10.1101/2024.05.29.596432

Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy

Valentino, T. R.·Burke, B. I.·Kang, G.·Goh, J.·Dungan, C. M.·Ismaeel, A.·Mobley, C. B.·Flythe, M. D.·Wen, Y.·McCarthy, J. J.

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Abstract

Regular exercise yields a multitude of systemic benefits, many of which may be mediated through the gut microbiome. Here, we report that cecal microbial transplants (CMTs) from exercise-trained vs. sedentary mice have modest benefits in reducing skeletal muscle atrophy using a mouse model of unilaterally hindlimb-immobilization. Direct administration of top microbial-derived exerkines from an exercise-trained gut microbiome preserved muscle function and prevented skeletal muscle atrophy.

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Valentino, T. R., Burke, B. I., Kang, G., Goh, J., Dungan, C. M., Ismaeel, A., Mobley, C. B., Flythe, M. D., Wen, Y., McCarthy, J. J.. 2024-06-02. Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy. https://doi.org/10.1101/2024.05.29.596432

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