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bioRxiv · 10.1101/2024.05.20.595024

The buoyancy of cryptococcal cells and its implications for transport and persistence of Cryptococcus in aqueous environments

Abstract

Cryptococcus is a genus of saprophytic fungi with global distribution. Two species complexes, C. neoformans and C. gattii, pose health risks to humans and animals. Cryptococcal infections result from inhalation of aerosolized spores and/or desiccated yeasts from terrestrial reservoirs such as soil, trees, and avian guano. More recently, C. gattii has been implicated in infections in marine mammals, suggesting that inhalation of liquid droplets or aerosols from the air-water interface is also an important, yet understudied, mode of respiratory exposure. Water transport has also been suggested to play a role in the spread of C. gattii from tropical to temperate environments. However, the dynamics of fungal survival, persistence, and transport via water have not been fully studied. The size of the cryptococcal capsule was previously shown to reduce cell density and increase buoyancy. Here, we demonstrate that cell buoyancy is also impacted by the salinity of the media in which cells are suspended, with formation of a halocline interface significantly slowing the rate of settling of cryptococcal cells through water, resulting in persistence of C. neoformans within 1 cm of the air-water interface for over 60 min and C. gattii for 4-6 h. Our data also showed that during culture in yeast peptone dextrose media (YPD), polysaccharide accumulating in the supernatant formed a raft that augmented buoyancy and further slowed settling of cryptococcal cells. These findings illustrate new mechanisms by which cryptococcal cells may persist in aquatic environments, with important implications for aqueous transport and pathogen exposure. ImportanceCryptococcosis is a major fungal disease leading to morbidity and mortality worldwide. C. neoformans is a major fungal species of public health concern, causing opportunistic systemic infections in immunocompromised patients. C. gattii was traditionally a tropical pathogen, but in the 1990s emerged in the temperate climates of British Columbia and the Pacific Northwest United States. Outbreaks in these areas also led to the first host record of cryptococcosis in free-ranging cetaceans. C. gattii is particularly concerning as an emerging fungal pathogen due to its capacity to cause clinical disease in immunocompetent patients, its recent spread to a new ecological niche, and its higher resistance to antifungal therapies. Our research defines characteristics that influence transport of cryptococci through water and its persistence at the air-water interface, which improve our understanding of mechanisms for cryptococcal aqueous transport and persistence.

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BibTeXRIS

Jimenez, I. A., Stempinski, P. R., Dragotakes, Q., Greengo, S. D., Sanchez Ramirez, L. R., Casadevall, A.. 2024-05-21. The buoyancy of cryptococcal cells and its implications for transport and persistence of Cryptococcus in aqueous environments. https://doi.org/10.1101/2024.05.20.595024

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