Impact of deprivation and preferential usage on functional connectivity between early visual cortex and category-selective visual regions

Abstract

Human behavior can be remarkably shaped by experience, such as the removal of sensory input. Many studies of conditions such as stroke, limb amputation, and vision loss have examined how the removal of input changes brain function. However, an important question has yet to be answered: when input is lost, does the brain change its connectivity to preferentially use some remaining inputs over others? In individuals with healthy vision, the central portion of the retina is preferentially used for everyday visual tasks, due to its ability to discriminate fine details. However, when central vision is lost in conditions like macular degeneration, peripheral vision must be relied upon for those everyday tasks, with certain portions receiving "preferential" usage over others. Using resting-state fMRI collected during total darkness, we examined how deprivation and preferential usage influence the intrinsic functional connectivity of sensory cortex by studying individuals with selective vision loss due to late stages of macular degeneration. We found that cortical regions representing spared portions of the peripheral retina, regardless of whether they are preferentially used, exhibit plasticity of intrinsic functional connectivity in macular degeneration. Cortical representations of spared peripheral retinal locations showed stronger connectivity to MT, a region involved in processing motion. These results suggest that long-term loss of central vision can produce widespread effects throughout spared representations in early visual cortex, regardless of whether those representations are preferentially used. These findings support the idea that connections to visual cortex maintain the capacity for change well after critical periods of visual development. HighlightsO_LIPortions of early visual cortex representing central vs. peripheral vision exhibit different patterns of connectivity to category-selective visual regions. C_LIO_LIWhen central vision is lost, cortical representations of peripheral vision display stronger functional connections to MT than central representations. C_LIO_LIWhen central vision is lost, connectivity to regions selective for tasks that involve central vision (FFA and PHA) are not significantly altered. C_LIO_LIThese effects do not depend on which locations of peripheral vision are used more. C_LI