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bioRxiv · 10.1101/2024.05.14.594096

Naphthalimide-based, Single-Chromophore, Ratiometric Fluorescent Sensor for Tracking Intracellular pH

Das, S. K.·Kahali, S.·Kar, S.·Madhavan, N.·Datta, A.
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Abstract

We report a novel, reversible, cell-permeable, pH-sensor, TRapH. TRapH afforded a pH-sensitive ratiometric emission response in the pH range [~]3-6, enabling imaging and quantification of pH in living cells. The biological-applicability of TRapH was illustrated via live-tracking of intracellular pH dynamics in living mammalian cells induced by a synthetic H+-transporter.

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Das, S. K., Kahali, S., Kar, S., Madhavan, N., Datta, A.. 2024-05-14. Naphthalimide-based, Single-Chromophore, Ratiometric Fluorescent Sensor for Tracking Intracellular pH. https://doi.org/10.1101/2024.05.14.594096

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