Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts

Szadai, L.; Bartha, A.; Parada, I. P.; Lakatos, A.; Pal, D.; Lengyel, A. S.; Almeida, N. P. d.; Janosi, A. J.; Nogueira, F.; Szeitz, B.; Doma, V.; Woldmar, N.; Guedes, J.; Ujfaludi, Z.; Pahi, Z. G.; Pankotai, T.; Kim, Y.; Gyorffy, B.; Baldetorp, B.; Welinder, C.; Szasz, A. M.; Betancourt, L.; Gil, J.; Appelqvist, R.; Kwon, H.-J.; Karpati, S.; Kuras, M.; Murillo, J. R.; Nemeth, I. B.; Malm, J.; Fenyo, D.; Pawlowski, K.; Horvatovich, P.; Wieslander, E.; Kemeny, L. V.; Domont, G.; Marko-Varga, G.; Sanchez, A.

doi:10.1101/2024.05.01.592032

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bioRxiv · 10.1101/2024.05.01.592032

Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts

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Abstract

While Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI therapy. Evaluating previously reported proteins in two untreated melanoma cohorts, we used a published predictive model (EaSIeR score) to identify potential proteins distinguishing responders and non-responders. Six proteins initially identified in the ICI cohort correlated with predicted response in the untreated cohort. Additionally, three proteins correlated with patient survival, both at the protein, and at the transcript levels, in an independent immunotherapy treated cohort. Our study identifies predictive biomarkers across three melanoma cohorts, suggesting their use in therapeutic decision-making. O_FIG O_LINKSMALLFIG WIDTH=164 HEIGHT=200 SRC="FIGDIR/small/592032v1_ufig1.gif" ALT="Figure 1"> View larger version (63K): org.highwire.dtl.DTLVardef@754668org.highwire.dtl.DTLVardef@1616263org.highwire.dtl.DTLVardef@827009org.highwire.dtl.DTLVardef@1899ba7_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Szadai, L., Bartha, A., Parada, I. P., Lakatos, A., Pal, D., Lengyel, A. S., Almeida, N. P. d., Janosi, A. J., Nogueira, F., Szeitz, B., Doma, V., Woldmar, N., Guedes, J., Ujfaludi, Z., Pahi, Z. G., Pankotai, T., Kim, Y., Gyorffy, B., Baldetorp, B., Welinder, C., Szasz, A. M., Betancourt, L., Gil, J., Appelqvist, R., Kwon, H.-J., Karpati, S., Kuras, M., Murillo, J. R., Nemeth, I. B., Malm, J., Fenyo, D., Pawlowski, K., Horvatovich, P., Wieslander, E., Kemeny, L. V., Domont, G., Marko-Varga, G., Sanchez, A.. 2024-05-04. Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts. https://doi.org/10.1101/2024.05.01.592032

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