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bioRxiv · 10.1101/2024.04.26.591236

Assessing genome conservation on pangenomegraphs with PanSel

Zytnicki, M.
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Abstract

1MotivationWith more and more telomere-to-telomere genomes assembled, pangenomes make it possible to capture the genomic diversity of a species. Because they introduce less biases, pangenomes, represented as graphs, tend to supplant the usual linear representation of a reference genome, augmented with variations. However, this major change requires new tools adapted to this data structure. Among the numerous questions that can be addressed to a pangenome graph is the search for conserved or divergent genes. ResultsIn this article, we present a new tool, named PanSel, which computes a conservation score for each segment of the genome, and finds genomic regions that are significantly conserved, or divergent. AvailabilityPanSel, written in C++11 with no dependency, is available at https://github.com/mzytnicki/pansel. Contactmatthias.zytnicki@inrae.fr

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Zytnicki, M.. 2024-04-28. Assessing genome conservation on pangenomegraphs with PanSel. https://doi.org/10.1101/2024.04.26.591236

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