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bioRxiv · 10.1101/2024.04.12.589196

Fetal protection against bovine viral diarrhea virus types 1 and 2 after vaccination of the dam with the DIVENCE vaccine

Taberner, E.·Gibert, M.·Montbrau, C.·Munoz, I.·Mallorqui, J.·Santo Tomas, H.·Prenafeta, A.·March, R.
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Abstract

The aim of this study was to demonstrate the efficacy of DIVENCE, a vaccine against BVDV types 1 and 2 (BVDV-1 and BVDV-2) transplacental infection, following a booster regimen in heifers. Calves of two-to-three months of age were given two intramuscular doses three weeks apart and a booster vaccine six months later. Efficacy was evaluated by means of a challenge with virulent BVDV-1 or BVDV-2 administered via the intranasal route at 85 days of gestation. Clinical signs, serology, viral shedding, WBC count and viremia were monitored after the challenge. Sixty-six days post-challenge, the fetuses were assessed for BVDV to detect transplacental infection. The results demonstrate a reduction in hyperthermia, leukopenia, viral shedding, and viremia in vaccinated animals post-challenge with BVDV-1 and BVDV-2. Most importantly, DIVENCE administered prior to breeding protected 94% of the fetuses against BVDV transplacental infection overall across both challenge trials (BVDV-1 and BVDV-2).

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Taberner, E., Gibert, M., Montbrau, C., Munoz, I., Mallorqui, J., Santo Tomas, H., Prenafeta, A., March, R.. 2024-04-15. Fetal protection against bovine viral diarrhea virus types 1 and 2 after vaccination of the dam with the DIVENCE vaccine. https://doi.org/10.1101/2024.04.12.589196

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