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bioRxiv · 10.1101/2024.04.10.588855

Tolerating B1+-inhomogeneity in MP2RAGE-based R1-mapping by calculating second contrast that permits previously problematic sequence parameters

Ruijters, L.·Lund, T. E.·Vinding, M. S.
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Abstract

PurposeRegarding in vivo, robust R1-mapping, the goal of the present paper is twofold. First, to verify that non-bijective mapping in MP2RAGE imaging can be resolved through a 2D look-up-table approach. Second, that the expanded parameter space from this can be used to improve B1+-inhomogeneity tolerance without other prerequisites. TheoryBy deriving a second contrast from the magnitude images of the MP2RAGE acquisition, ambiguities in the original MP2RAGE image resulting from non-bijective transfer curves can be resolved. Such ambiguities may occur when protocols are optimised, e.g., for higher B1+-inhomogeneity tolerance. A 2D look-up-table approach combines the available information to resolve these ambiguities during mapping. MethodsAt 3T, we acquired MP2RAGE images with standard acquisition parameters and (non-bijective) parameters optimised for B1+-inhomogeneity tolerance. From three subjects across multiple sessions, we assessed the B1+-inhomogeneity tolerance through excitation pulse amplitude scalings. ResultsThe R1-maps resulting from the B1+-optimised protocols showed greatly reduced B1+-effects across images, but without additional scanner time. Meanwhile these maps could only successfully be derived by a 2D look-up-table approach. ConclusionWe show that it is possible to optimise for B1+-inhomogeneity tolerance in MP2RAGE through sequence parameter settings, while still successfully estimating the R1-map with a 2D look-up-table approach. This without the need for an additional B1+-map. The increased parameter space enabled by the 2D look-up-table approach may further be used to adjust MP2RAGE acquisitions for improved scan times, SNR and/or CNR.

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Ruijters, L., Lund, T. E., Vinding, M. S.. 2024-04-13. Tolerating B1+-inhomogeneity in MP2RAGE-based R1-mapping by calculating second contrast that permits previously problematic sequence parameters. https://doi.org/10.1101/2024.04.10.588855

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