EMERGENCE OF OXA-48-LIKE CARBAPENEMASES IN CLINICAL ENTEROBACTERALES FROM GUATEMALA

Mazariegos, C. J.; Quinto, A.; Herrera, A.; Barillas, S. E.; Valenzuela, L. R.; Ordonez, G.; Sierra, P.; Arevalo, C.; Seah, C.; Melano, R. G.

doi:10.1101/2024.04.04.588149

bioRxiv · 10.1101/2024.04.04.588149

EMERGENCE OF OXA-48-LIKE CARBAPENEMASES IN CLINICAL ENTEROBACTERALES FROM GUATEMALA

Mazariegos, C. J.·Quinto, A.·Herrera, A.·Barillas, S. E.·Valenzuela, L. R.·Ordonez, G.·Sierra, P.·Arevalo, C.·Seah, C.·Melano, R. G.

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Abstract

Five isolates (four Klebsiella pneumoniae and one Escherichia coli) displaying resistance to piperacillin/tazobactam and ertapenem and reduced susceptibility to imipenem were found positive for blaOXA-48-like genes (blaOXA-181 and blaOXA-232) carried on plasmids described previously. Although two K. pneumoniae recovered in 2020 were clonally related, the results suggest that blaOXA-48-like genes have been circulating in Guatemala since 2019. This is the first report of this type of carbapenemase in Central America.

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Mazariegos, C. J., Quinto, A., Herrera, A., Barillas, S. E., Valenzuela, L. R., Ordonez, G., Sierra, P., Arevalo, C., Seah, C., Melano, R. G.. 2024-04-07. EMERGENCE OF OXA-48-LIKE CARBAPENEMASES IN CLINICAL ENTEROBACTERALES FROM GUATEMALA. https://doi.org/10.1101/2024.04.04.588149

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