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bioRxiv · 10.1101/2024.03.24.586474

Design of a sequestration-based network with tunable pulsing dynamics

Nakamura, E.·Cuba Samaniego, C.·Blanchini, F.·Giordano, G.·Franco, E.
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Abstract

Incoherent feedforward networks exhibit the ability to generate temporal pulse behavior. However, exerting control over specific dynamic properties, such as amplitude and rise time, poses a challenge and is intricately tied to the networks implementation. In this study, we focus on analyzing sequestration-based networks capable of exhibiting pulse behavior. By employing time-scale separation in the fast sequestration regime, we approximate the temporal dynamics of these networks. This approach allows us to establish a mapping that elucidates the impact of varying the kinetic rates and pulse specifications, including amplitude and rise time. Furthermore, we introduce a positive feedback mechanism to regulate the amplitude of the pulsing response.

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Nakamura, E., Cuba Samaniego, C., Blanchini, F., Giordano, G., Franco, E.. 2024-03-24. Design of a sequestration-based network with tunable pulsing dynamics. https://doi.org/10.1101/2024.03.24.586474

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