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bioRxiv · 10.1101/2024.03.22.586241

Design of Antigen-Specific Antibody CDRH3 Sequences Using AI and Germline-Based Templates

Marinov, T. M.·Abu-Shmais, A.·Janke, A. K.·Georgiev, I.
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Abstract

Antibody-antigen specificity is engendered and refined through a number of complex B cell processes, including germline gene recombination and somatic hypermutation. Here, we present an AI-based technology for de novo generation of antigen-specific antibody CDRH3 sequences using germline-based templates, and validate this technology through the generation of antibodies against SARS-CoV-2. AI-based processes that mimic the outcome, but bypass the complexity of natural antibody generation, can be efficient and effective alternatives to traditional experimental approaches for antibody discovery.

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Marinov, T. M., Abu-Shmais, A., Janke, A. K., Georgiev, I.. 2024-03-22. Design of Antigen-Specific Antibody CDRH3 Sequences Using AI and Germline-Based Templates. https://doi.org/10.1101/2024.03.22.586241

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