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bioRxiv · 10.1101/2024.03.18.585493

collectNET: a web server for integrated inference of cell-cell communication network

Pan, Y.·Gao, Z.·Cui, X.·Li, Z.·Jiang, R.
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Abstract

SummaryCell-cell communication through ligand-receptor pairs forms the cornerstone for complex functionalities in multicellular organisms. Deciphering such intercellular signaling can contribute to un-raveling disease mechanisms and enables targeted therapy. Nonetheless, notable biases and inconsistencies are evident among the inferential outcomes generated by current methods for inferring cell-cell communication network. To fill this gap, we developed collectNET (http://health.tsing-hua.edu.cn/collectnet) as the first web server for efficiently inferring the cell-cell communication network, with efficient calculation, hierarchical browsing, comprehensive statistics, advanced searching, and intuitive visualization. collectNET provides a reliable online inference service with prior knowledge of three public ligand-receptor databases and systematic integration of three mainstream inference methods. Additionally, collectNET has assembled a human cell-cell communication atlas, including 126,785 significant communication pairs based on 343,023 single cells. We anticipate that collectNET will benefit researchers in gaining a more holistic understanding of cell development and differentiation mechanisms. Availability and ImplementationcollectNET is freely available at http://health.tsinghua.edu.cn/collectnet. Contactruijiang@tsinghua.edu.cn Supplementary informationSupplementary data are available at Bioinformatics online.

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Pan, Y., Gao, Z., Cui, X., Li, Z., Jiang, R.. 2024-03-20. collectNET: a web server for integrated inference of cell-cell communication network. https://doi.org/10.1101/2024.03.18.585493

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