Characterizing an electronic-robotic targeting platform for precise and fast brain stimulation with multi-locus transcranial magnetic stimulation

Matsuda, R. H.; Souza, V. H.; Marchetti, T.; De La Cruz, A. S.; Kahilakoski, O.-P.; Laine, M.; Sinisalo, H.; Kicic, D.; Lioumis, P.; Ilmoniemi, R.; Baffa, O.

doi:10.1101/2024.03.12.584601

bioRxiv · 10.1101/2024.03.12.584601

Characterizing an electronic-robotic targeting platform for precise and fast brain stimulation with multi-locus transcranial magnetic stimulation

Matsuda, R. H.·Souza, V. H.·Marchetti, T.·De La Cruz, A. S.·Kahilakoski, O.-P.·Laine, M.·Sinisalo, H.·Kicic, D.·Lioumis, P.·Ilmoniemi, R.·Baffa, O.

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Abstract

1.BackgroundMulti-locus TMS (mTMS) enables precise electronic control of brain stimulation targeting, eliminating the need for physical coil movement. However, with a small number of coils, the stimulation area is constrained, and manually handling the coil array is cumbersome. Combining electronic mTMS targeting with robotics will enable automated, user-independent, and precise brain stimulation protocols. ObjectiveCharacterizing an open-source electronic-robotic mTMS platform for rapid and accurate brain stimulation targeting. MethodsWe developed an automated robotic mTMS positioning platform. The accuracy of the system was quantified with a TMS characterizer that measures the TMS-induced electric field on a spherical cortex model. We used a 5-coil mTMS device equipped with a set of five coils coupled to a collaborative robot. The induced electric-field distortion generated by robot coupling was evaluated for each coil. We compared the accuracy of robotic-electronic targeting by repositioning the mTMS coil set with the robotic and the conventional manual positioning. ResultsOur collaborative robot-based system offers submillimeter precision and autonomy in positioning mTMS coil sets. The electronic-robotic mTMS platform was approximately 1.8 mm and 1.0{degrees} more accurate than the conventional manual positioning. Integrating robotics and mTMS automates brain stimulation procedures, resulting in minimal reliance on user expertise and subjective analysis. ConclusionOur open-source platform combining rapid mTMS targeting with robotic precision enhances the safety and reproducibility of brain stimulation techniques, enabling more efficient and reliable outcomes than previous techniques.

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Matsuda, R. H., Souza, V. H., Marchetti, T., De La Cruz, A. S., Kahilakoski, O.-P., Laine, M., Sinisalo, H., Kicic, D., Lioumis, P., Ilmoniemi, R., Baffa, O.. 2024-03-14. Characterizing an electronic-robotic targeting platform for precise and fast brain stimulation with multi-locus transcranial magnetic stimulation. https://doi.org/10.1101/2024.03.12.584601

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