In-Space Fabrication of Janus Base Nano-Matrix for Improved Assembly and Bioactivities

Yau, A.; Landolina, M.; Snow, M. A.; Mesci, P.; Williams, B.; Hoying, J. B.; Duflo, D.; Wu, H.; Stoudemire, J.; Hernandez, R.; Chen, Y.

doi:10.1101/2024.03.11.584527

bioRxiv · 10.1101/2024.03.11.584527

In-Space Fabrication of Janus Base Nano-Matrix for Improved Assembly and Bioactivities

Yau, A.·Landolina, M.·Snow, M. A.·Mesci, P.·Williams, B.·Hoying, J. B.·Duflo, D.·Wu, H.·Stoudemire, J.·Hernandez, R.·Chen, Y.

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Abstract

In-space manufacturing of nanomaterials is a promising concept while having limited successful examples. DNA-inspired Janus base nanomaterials (JBNs), used for therapeutics delivery and tissue regeneration, are fabricated via a controlled self-assembly process in water at ambient temperature, making them highly suitable for in-space manufacturing. For the first time, we designed and accomplished the production of JBNs on orbit during the Axiom-2 (Ax-2) mission demonstrating great promising and benefits of in-space manufacturing of nanomaterials.

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Yau, A., Landolina, M., Snow, M. A., Mesci, P., Williams, B., Hoying, J. B., Duflo, D., Wu, H., Stoudemire, J., Hernandez, R., Chen, Y.. 2024-03-14. In-Space Fabrication of Janus Base Nano-Matrix for Improved Assembly and Bioactivities. https://doi.org/10.1101/2024.03.11.584527

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