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bioRxiv · 10.1101/2024.02.28.582465

Illuminating the functional landscape of the dark proteome across the Animal Tree of Life through natural language processing models

Martinez-Redondo, G. I.·Barrios-Nunez, I.·Vazquez-Valls, M.·Rojas, A. M.·Fernandez, R.
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Abstract

Functional annotation is crucial in biology, but many protein-coding genes remain uncharacterized, especially in non-model organisms. FANTASIA (Functional ANnoTAtion based on embedding space SImilArity) integrates protein language models for large-scale functional annotation. Applied to [~]1,000 animal proteomes, it predicts functions to virtually all proteins, revealing previously uncharacterized functions that enhance our understanding of molecular evolution. FANTASIA is available on GitHub at https://github.com/CBBIO/FANTASIA.

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Martinez-Redondo, G. I., Barrios-Nunez, I., Vazquez-Valls, M., Rojas, A. M., Fernandez, R.. 2024-02-29. Illuminating the functional landscape of the dark proteome across the Animal Tree of Life through natural language processing models. https://doi.org/10.1101/2024.02.28.582465

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