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bioRxiv · 10.1101/2024.02.23.581752

Extended blood stage sensitivity profiles of Plasmodium vivax to doxycycline and tafenoquine using Plasmodium cynomolgi as a model

Christensen, P.·Cinzah, R.·Suwanarusk, R.·Chua, A. C. Y.·Kaneko, O.·Kyle, D. E.·Aung, H. L.·Matheson, J.·Bifani, P.·Renia, L.·Cook, G. M.·Snounou, G.·Russell, B. M.
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Abstract

Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which precludes determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. vivax, we determined the physiologically significant delayed death effect induced by doxycycline (IC50(96h), 1401 {+/-} 607 nM). As expected, IC50(96 h) to chloroquine (20.4 nM), piperaquine (12.6 {micro}M) and tafenoquine (1424 nM) were not affected by extended exposure.

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Christensen, P., Cinzah, R., Suwanarusk, R., Chua, A. C. Y., Kaneko, O., Kyle, D. E., Aung, H. L., Matheson, J., Bifani, P., Renia, L., Cook, G. M., Snounou, G., Russell, B. M.. 2024-02-28. Extended blood stage sensitivity profiles of Plasmodium vivax to doxycycline and tafenoquine using Plasmodium cynomolgi as a model. https://doi.org/10.1101/2024.02.23.581752

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