Model-Based Estimation of Active and Passive Muscle Forces Using MRE in Forearm Muscles During 2-DOF Wrist Tasks

Abstract

Magnetic resonance elastography (MRE)-based muscle force estimation methods have been proposed to estimate individual muscle forces based on measurements of shear wave speed and joint torque in multiple postures. To estimate both the slope and offset parameters of the relationship between shear wave speed and muscle force, it is necessary to collect measurements in a plethora of postures in case of substantial muscle redundancy. However, anisotropic MRE requires a structural and diffusion-tensor imaging scan in each posture, which is infeasible given the time constraints of MRI imaging. The objectives of this work were to develop a muscle force estimator with sufficient accuracy that would only require a limited set of postures, and to evaluate its effectiveness under a variety of measurement conditions. We developed a novel MRE-based muscle force estimator, which decouples shear wave speed into its active and passive components and solves for the slope and offset parameters, independently. We assessed the effectiveness of the proposed estimator under different simulated measurement conditions, with varying levels of noise, and compared it to the original MRE-based estimator. The proposed estimator results in a reduction in the estimation error for the offset parameter, for all muscles, without significant degradation in the estimation error for the slope parameter. However, the proposed muscle force estimator does not improve the goodness-of-fit or the cross-validation error compared to the original estimator. In conclusion, the proposed MRE-based muscle force estimator improves the estimation of muscle-specific parameters and may yield increased muscle force estimation performance.