Fine-scale genetic structure and rare variant frequencies

Gagnon, L.; Moreau, C.; Laprise, C.; Girard, S. L.

doi:10.1101/2024.02.02.578687

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bioRxiv · 10.1101/2024.02.02.578687

Fine-scale genetic structure and rare variant frequencies

Gagnon, L.·Moreau, C.·Laprise, C.·Girard, S. L.

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Abstract

In response to the current challenge in genetic studies to make new associations, we advocate for a shift toward leveraging population fine-scale structure. Our exploration brings to light distinct fine-structure within populations having undergone a founder effect, challenging the prior perception of homogeneity. This underscores that smaller, but well-defined cohorts, demonstrate an important increase in rare variant frequencies, offering a promising avenue for new genetic variants discovery.

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Gagnon, L., Moreau, C., Laprise, C., Girard, S. L.. 2024-02-07. Fine-scale genetic structure and rare variant frequencies. https://doi.org/10.1101/2024.02.02.578687

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