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bioRxiv · 10.1101/2024.01.29.577775

Xylan inhibition of cellulase binding and processivity observed at single-molecule resolution

Abstract

Efficient cellulose degradation by cellulase enzymes is crucial for using lignocellulosic biomass in bioenergy production. In the cell wall of plants, cellulose is bound by lignin and hemicellulose, which are key factors contributing to the recalcitrance of plant biomass. These non-cellulosic cell wall components are known to interfere with the function of cellulolytic enzymes. While the effects of lignin have been studied extensively, the contribution of xylan, the major hemicellulose in the secondary cell walls of plants, is often overlooked. To study those effects, we generated model cell wall composites by growing bacterial cellulose supplemented with varying concentrations of purified xylan. We used single-molecule microscopy to image and track fluorescently labeled TrCel7A, a commonly used model cellulase, as it binds and hydrolyses cellulose in these synthetic composites. We found that minute amounts of xylan are sufficient to significantly inhibit the binding of Cel7A to cellulose. The inclusion of xylan also reduced considerably the proportion of moving enzyme molecules, without affecting their velocity and run length. We suggest that, when available at low concentrations, xylan thinly coats cellulose fibrils, and incorporates as continuous patches when available at higher concentrations. Non-productive binding of Cel7A to xylan was not found to be a major inhibition mechanism. Our results highlight the importance of targeting xylan removal during biomass processing and demonstrate the potential of using single-molecule imagining to study the activity and limitations of cellulolytic enzymes. Graphical abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=165 SRC="FIGDIR/small/577775v1_ufig1.gif" ALT="Figure 1"> View larger version (21K): org.highwire.dtl.DTLVardef@1c7afbeorg.highwire.dtl.DTLVardef@e30ce4org.highwire.dtl.DTLVardef@635358org.highwire.dtl.DTLVardef@f4bdc9_HPS_FORMAT_FIGEXP M_FIG C_FIG

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BibTeXRIS

Zexer, N., Paradiso, A., Nong, D., Haviland, Z. K., Hancock, W. O., Anderson, C. T.. 2024-01-29. Xylan inhibition of cellulase binding and processivity observed at single-molecule resolution. https://doi.org/10.1101/2024.01.29.577775

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