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bioRxiv · 10.1101/2024.01.04.574051

Morphological deficits of glial cells in a transgenic mouse model for developmental stuttering

Adeck, A.·Millwater, M.·Bragg, C.·Zhang, R.·SheikhBahaei, S.
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Abstract

Vocal production involves intricate neural coordination across various brain regions. Stuttering, a common speech disorder, has genetic underpinnings, including mutations in lysosomal-targeting pathway genes. Using a Gnptab-mutant mouse model linked to stuttering, we examined neuron and glial cell morphology in vocal production circuits. Our findings revealed altered astrocyte and microglia processes in these circuits in Gnptab-mutant mice, while control regions remained unaffected. Our results shed light on the potential role of glial cells in stuttering pathophysiology and highlight their relevance in modulating vocal production behaviors.

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Adeck, A., Millwater, M., Bragg, C., Zhang, R., SheikhBahaei, S.. 2024-01-05. Morphological deficits of glial cells in a transgenic mouse model for developmental stuttering. https://doi.org/10.1101/2024.01.04.574051

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