Development of a PROTAC Targeting Chk1

Chowdhury, S. R.; Chuong, P.; Mgbemena, V. E.; Statsyuk, A. V.

doi:10.1101/2023.12.30.573733

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bioRxiv · 10.1101/2023.12.30.573733

Development of a PROTAC Targeting Chk1

Chowdhury, S. R.·Chuong, P.·Mgbemena, V. E.·Statsyuk, A. V.

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Abstract

A series of Chk1 degraders were designed and synthesized. The degraders were developed through the conjugation of a promiscuous kinase binder and thalidomide. One of the degraders PROTAC-2 was able to decrease Chk1 levels in a concentration-dependent manner in A375 cells. The developed probes can be useful for the development of selective and more potent Chk1 degraders.

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Chowdhury, S. R., Chuong, P., Mgbemena, V. E., Statsyuk, A. V.. 2024-01-01. Development of a PROTAC Targeting Chk1. https://doi.org/10.1101/2023.12.30.573733

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