Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing

Wan, J.; Nie, Z.; Xu, J.; Zhang, Z.; Yao, S.; Xiang, Z.; Lin, X.; Lu, Y.; Xu, C.; Zhao, P.; Wang, Y.; Zhang, J.; Zhang, S.; Wang, J.; Man, W.; Zhang, M.; Han, M.

doi:10.1101/2023.11.23.568392

bioRxiv · 10.1101/2023.11.23.568392

Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing

Wan, J.·Nie, Z.·Xu, J.·Zhang, Z.·Yao, S.·Xiang, Z.·Lin, X.·Lu, Y.·Xu, C.·Zhao, P.·Wang, Y.·Zhang, J.·Zhang, S.·Wang, J.·Man, W.·Zhang, M.·Han, M.

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Abstract

Implantable sensors can directly interface with various organs for precise evaluation of health status. However, extracting signals from such sensors must rely on transcutaneous wires, integrated circuit chips, or cumbersome readout equipment, which increases the risks of infection, reduces the biocompatibility, or limits the portability. Here, we develop a set of millimeter-scale, chip-less and battery-less magnetic implants that can measure biophysical and biochemical signals wirelessly. In particular, the implants form two-way communications with a fully integrated wearable device, where the wearable device can induce a large-amplitude damped vibration of the magnetic implants and capture their subsequent motions in a wireless manner. Such damped vibrations reflect not only the biophysical conditions surrounding the implants movements, but also the concentration of a specific biochemical depending on the surface modification. Experiments in rat models demonstrate the capabilities in measuring cerebrospinal fluid (CSF) viscosity, intracranial pressure (ICP), and CSF glucose levels. This miniaturized system opens possibility for continuous, wireless monitoring of a wide range of biophysical and biochemical conditions within the living organism.

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Wan, J., Nie, Z., Xu, J., Zhang, Z., Yao, S., Xiang, Z., Lin, X., Lu, Y., Xu, C., Zhao, P., Wang, Y., Zhang, J., Zhang, S., Wang, J., Man, W., Zhang, M., Han, M.. 2023-11-23. Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing. https://doi.org/10.1101/2023.11.23.568392

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