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bioRxiv · 10.1101/2023.11.22.568309

SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest

Guerrero, V. L. L.·Di Bernardo, M.·Hardy, W. R.·Sutoski, J. C.·MacNeil, L. T.
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Abstract

Shc proteins function in many different signaling pathways where they mediate phosphorylation-dependent protein-protein interactions. These proteins are characterized by the presence of two phosphotyrosine-binding domains, an N-terminal PTB and a C-terminal SH2. We describe a previously unrecognized C. elegans Shc gene, shc-3 and characterize its role of in stress response. Both shc-3 and shc-1 are required for long-term survival in L1 arrest, however, they do not act redundantly but rather play distinct roles in this process. SHC-3 function in survival during L1 arrest is DAF-16-dependent, demonstrating that like SHC-1, SHC-3 functions in the Insulin-like signaling pathway. In the absence of SHC-3, nuclear entry and exit are slowed suggesting that SHC-3 is required for rapid changes in DAF-16 signaling.

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Guerrero, V. L. L., Di Bernardo, M., Hardy, W. R., Sutoski, J. C., MacNeil, L. T.. 2023-11-22. SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest. https://doi.org/10.1101/2023.11.22.568309

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