Unravelling the neural dynamics of hypnotic susceptibility: Aperiodic neural activity as a central feature of hypnosis

Abstract

How well a person responds to hypnosis is a stable trait, which exhibits considerable inter-individual diversity across the general population. Yet, its neural underpinning remains elusive. Here, we address this gap by combining EEG data, multivariate statistics, and machine learning in order to identify brain patterns that differentiate between individuals high and low in susceptibility to hypnosis. In particular, we computed the periodic and aperiodic components of the EEG power spectrum, as well as graph theoretical measures derived from functional connectivity, from data acquired at rest (pre-induction) and under hypnosis (post-induction). We found that the 1/f slope of the EEG spectrum at rest was the best predictor of hypnotic susceptibility. Our findings support the idea that hypnotic susceptibility is a trait linked to the balance of cortical excitation and inhibition at baseline and offers novel perspectives on the neural foundations of hypnotic susceptibility. Future work can explore the contribution of background 1/f activity as a novel target to distinguish the responsiveness of individuals to hypnosis at baseline in the clinic. Significance StatementHypnotic phenomena reflect the ability to alter ones subjective experiences based on targeted verbal suggestions. This ability varies greatly in the population. The brain correlates to explain this variability remain elusive. Addressing this gap, our study employs machine learning to predict hypnotic susceptibility. By recording electroencephalography (EEG) before and after a hypnotic induction and analyzing diverse neurophysiological features, we were able to determine that several features differentiate between high and low hypnotic susceptible individuals both at baseline and during hypnosis. Our analysis revealed that the paramount discriminative feature is non-oscillatory EEG activity before the induction--a new finding in the field. This outcome aligns with the idea that hypnotic susceptibility represents a latent trait observable through a plain five-minutes resting-state EEG.