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bioRxiv · 10.1101/2023.11.13.566808

Effects of high fat and sugar diet on motivation for food and resistance to punishment in rats: role of sex and age of exposure

Desmercieres, S.·Lardeux, V.·Longueville, J.-E.·Dugast, E.·Thiriet, N.·Solinas, M.
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Abstract

Exposure to food rich in fat and sugar (High Fat and Sugar Diet, HFSD) is believed to induce behavioral and neurobiological changes that would produce addiction-like behavior and increase the risks of obesity and overweight. Studies in rodents have led to conflicting results suggesting that several factors such as sex and age of exposure contribute to the development of maladaptive behavior towards food. In addition, it is not clear whether the effects of exposure to HFSD persist after its discontinuation which would indicate long-term risk to develop addiction-like behavior. In this study, we investigated the persistent effects of an intermittent 8-week exposure to HFSD in male and female rats as a function of age of exposure (adult and adolescent). We found that intermittent exposure to HFSD did not alter body weight, but it affected consumption of standard food during the time of exposure in all groups. In addition, in adults, HFSD produced a decrease in the initial baseline responding in FR1 schedules that persisted for 4 weeks in males but not in female rats. However, we found that exposure to HFSD did not affect resistance to punishment measured by progressive shock strength (PSS) break points or motivation for food measured by progressive-ratio break points regardless of sex or age of exposure. Altogether, these results do not provide support to the hypothesis that intermittent exposure to HFSD produce persistent increases in the vulnerability to develop addiction-like behaviors towards palatable food.

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Desmercieres, S., Lardeux, V., Longueville, J.-E., Dugast, E., Thiriet, N., Solinas, M.. 2023-11-13. Effects of high fat and sugar diet on motivation for food and resistance to punishment in rats: role of sex and age of exposure. https://doi.org/10.1101/2023.11.13.566808

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