A single locus determines praziquantel response in Schistosoma mansoni

Chevalier, F. D.; Le Clec'h, W.; Berriman, M.; Anderson, T.

doi:10.1101/2023.11.01.565202

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bioRxiv · 10.1101/2023.11.01.565202

A single locus determines praziquantel response in Schistosoma mansoni

Chevalier, F. D.·Le Clec'h, W.·Berriman, M.·Anderson, T.

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Abstract

We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci (QTL) situated on chromosome 2 and chromosome 3. We reanalyzed this GWAS using the latest (v10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that praziquantel response is monogenic and demonstrates the importance of high-quality genomic information.

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Chevalier, F. D., Le Clec'h, W., Berriman, M., Anderson, T.. 2023-11-04. A single locus determines praziquantel response in Schistosoma mansoni. https://doi.org/10.1101/2023.11.01.565202

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