Ventral hippocampus neurons encode meal-related memory

Decarie-Spain, L.; Gu, C.; Tierno Lauer, L.; Subramanian, K. S.; Chehimi, S. N.; Kao, A. E.; Deng, I.; Bashaw, A. G.; Klug, M. E.; Hewage Galbokke, A.; Donohue, K. N.; Yang, M.; de Lartigue, G.; Myers, K. P.; Crist, R. C.; Reiner, B. C.; Hayes, M. R.; Kanoski, S.

doi:10.1101/2023.10.10.561731

bioRxiv · 10.1101/2023.10.10.561731

Ventral hippocampus neurons encode meal-related memory

Decarie-Spain, L.·Gu, C.·Tierno Lauer, L.·Subramanian, K. S.·Chehimi, S. N.·Kao, A. E.·Deng, I.·Bashaw, A. G.·Klug, M. E.·Hewage Galbokke, A.·Donohue, K. N.·Yang, M.·de Lartigue, G.·Myers, K. P.·Crist, R. C.·Reiner, B. C.·Hayes, M. R.·Kanoski, S.

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Abstract

The ability to encode and retrieve meal-related information is critical to efficiently guide energy acquisition and consumption, yet the underlying neural processes remain elusive. Here we reveal that ventral hippocampus (HPCv) neuronal activity dynamically elevates during meal consumption and this response is highly predictive of subsequent performance in a foraging-related spatial memory task. Targeted recombination-mediated ablation of HPCv meal-responsive neurons impairs foraging-related spatial memory without influencing food motivation, anxiety-like behavior, or escape-mediated spatial memory. These HPCv meal-responsive neurons project to the lateral hypothalamic area (LHA) and single-nucleus RNA sequencing and in situ hybridization analyses indicate they are enriched in serotonin 2a receptors (5HT2aR). Either chemogenetic silencing of HPCv-to-LHA projections or intra-HPCv 5HT2aR antagonist yielded foraging-related spatial memory deficits, as well as alterations in caloric intake and the temporal sequence of spontaneous meal consumption. Collective results identify a population of HPCv neurons that dynamically respond to eating to encode meal-related memories.

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Decarie-Spain, L., Gu, C., Tierno Lauer, L., Subramanian, K. S., Chehimi, S. N., Kao, A. E., Deng, I., Bashaw, A. G., Klug, M. E., Hewage Galbokke, A., Donohue, K. N., Yang, M., de Lartigue, G., Myers, K. P., Crist, R. C., Reiner, B. C., Hayes, M. R., Kanoski, S.. 2023-10-10. Ventral hippocampus neurons encode meal-related memory. https://doi.org/10.1101/2023.10.10.561731

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