SARS-CoV-2 antibodies cross-react and enhance dengue infection

Jakhar, K.; Sonar, S.; Singh, G.; Sarkar, T.; Tiwari, M.; Kaur, J.; Rathore, D. K.; Lal, B.; Kumar, S.; Srivastav, P.; Phagna, V.; Kumar, L.; Gupta, V.; Kshetrapal, P.; Singh, S.; Wadhwa, N.; Thiruvengadam, R.; Raghavan, S.; Gosain, M.; Shrivastava, T.; Bhattacharyya, S.; Bhattacharya, J.; Asthana, S.; Mani, S.

doi:10.1101/2023.10.09.557914

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bioRxiv · 10.1101/2023.10.09.557914

SARS-CoV-2 antibodies cross-react and enhance dengue infection

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Abstract

The presence of non-neutralizing antibodies of any dengue serotype, increase the severity of subsequent infection by other dengue serotypes. During SARS-CoV-2 pandemic, the number of symptomatic dengue cases increased in India. We describe that antibodies isolated from convalescent plasma from COVID-19 patients enhances DENV2 infection in vitro. CR3022, one antibody against SARS-CoV-2 spike protein, also showed elevated DENV2 infection in vitro. In silico protein-protein interactions between the spike antibodies and the DENV2 E-protein revealed significant interactions. Likewise, few monoclonal/polyclonal antibodies against SARS-CoV-2 showed increased dengue infection in vitro. Importantly, the AG129 mice infected with SARS-CoV-2 three-weeks prior to DENV2 infection, showed elevated dengue pathogenesis. Thus, highlighting the possibilities of elevated infection and symptomatic dengue disease in COVID-19 survivors.

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Jakhar, K., Sonar, S., Singh, G., Sarkar, T., Tiwari, M., Kaur, J., Rathore, D. K., Lal, B., Kumar, S., Srivastav, P., Phagna, V., Kumar, L., Gupta, V., Kshetrapal, P., Singh, S., Wadhwa, N., Thiruvengadam, R., Raghavan, S., Gosain, M., Shrivastava, T., Bhattacharyya, S., Bhattacharya, J., Asthana, S., Mani, S.. 2023-10-10. SARS-CoV-2 antibodies cross-react and enhance dengue infection. https://doi.org/10.1101/2023.10.09.557914

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