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bioRxiv · 10.1101/2023.10.02.560392

Rolling 2D Bioelectronic film into 1D: a Suturable Long-term Implantable Soft Microfiber

Xie, R.·Yu, Q.·Li, D.·Han, X.·Xu, X.·Huang, J.·Zhou, X.·Tian, Q.·Li, Q.·Li, H.·Li, G.·Han, F.·Xu, T.·Liu, Z.
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Abstract

Long-term implantable bioelectronics can efficiently evaluate the function of the nervous system. 1D fiber-shaped devices require small surgical incisions significantly benefiting long-term biocompatibility. We report a strategy of rolling to reduce the dimension of bioelectronic devices from 2D film to 1D microfiber. The soft and stretchable multifunctional microfiber accommodates more than 60-channel longitudinally-distributed electrodes for bio-electric and -mechanical monitoring. It can be sutured into muscle with tiny incision for 8-month bio-electrical monitoring in rats. Importantly, after 13-month implantation, the fibroblast encapsulation around the fiber is negligible. Moreover, it can wander inside a brain under magnetic field. This strategy not only opens up the study of multi-channel and -function soft and stretchable fiber-shaped sensors but offers a platform for minimally-invasive implantable bioelectronics. One-Sentence SummaryThe rolling enables stretchable electrode array along one single microfiber and multimodal long-term in-vivo monitoring.

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Xie, R., Yu, Q., Li, D., Han, X., Xu, X., Huang, J., Zhou, X., Tian, Q., Li, Q., Li, H., Li, G., Han, F., Xu, T., Liu, Z.. 2023-10-03. Rolling 2D Bioelectronic film into 1D: a Suturable Long-term Implantable Soft Microfiber. https://doi.org/10.1101/2023.10.02.560392

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