Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets

Meliopoulos, V. A.; Honce, R.; Livingston, B.; Hargest, V.; Freiden, P.; Lazure, L.; Brigleb, P. H.; Karlsson, E. A.; Tillman, H.; Allen, E. K.; Boyd, D.; Thomas, P.; Schultz-Cherry, S.

doi:10.1101/2023.09.26.558609

bioRxiv · 10.1101/2023.09.26.558609

Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets

Meliopoulos, V. A.·Honce, R.·Livingston, B.·Hargest, V.·Freiden, P.·Lazure, L.·Brigleb, P. H.·Karlsson, E. A.·Tillman, H.·Allen, E. K.·Boyd, D.·Thomas, P.·Schultz-Cherry, S.

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Abstract

Obesity, and the associated metabolic syndrome, is a risk factor for increased disease severity with a variety of infectious agents, including influenza virus. Yet the mechanisms are only partially understood. As the number of people, particularly children, living with obesity continues to rise, it is critical to understand the role of host status on disease pathogenesis. In these studies, we use a novel diet-induced obese ferret model and new tools to demonstrate that like humans, obesity resulted in significant changes to the lung microenvironment leading to increased clinical disease and viral spread to the lower respiratory tract. The decreased antiviral responses also resulted in obese animals shedding higher infectious virus for longer making them more likely to transmit to contacts. These data suggest the obese ferret model may be crucial to understanding obesitys impact on influenza disease severity and community transmission, and a key tool for therapeutic and intervention development for this high-risk population. TeaserA new ferret model and tools to explore obesitys impact on respiratory virus infection, susceptibility, and community transmission.

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Meliopoulos, V. A., Honce, R., Livingston, B., Hargest, V., Freiden, P., Lazure, L., Brigleb, P. H., Karlsson, E. A., Tillman, H., Allen, E. K., Boyd, D., Thomas, P., Schultz-Cherry, S.. 2023-09-26. Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets. https://doi.org/10.1101/2023.09.26.558609

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