Ventrointermediate thalamic stimulation improves motor learning in humans

Voegtle, A.; Terzic, L.; Farahat, A.; Hartong, N.; Galazky, I.; Hinrichs, H.; Nasuto, S. J.; de Oliveira Andrade, A.; Knight, R. T.; Ivry, R. B.; Voges, J.; Deliano, M.; Buentjen, L.; Sweeney-Reed, C. M.

doi:10.1101/2023.09.19.558378

bioRxiv · 10.1101/2023.09.19.558378

Ventrointermediate thalamic stimulation improves motor learning in humans

Voegtle, A.·Terzic, L.·Farahat, A.·Hartong, N.·Galazky, I.·Hinrichs, H.·Nasuto, S. J.·de Oliveira Andrade, A.·Knight, R. T.·Ivry, R. B.·Voges, J.·Deliano, M.·Buentjen, L.·Sweeney-Reed, C. M.

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Abstract

Ventrointermediate thalamic stimulation (VIM-DBS) modulates oscillatory activity in a cortical network including primary motor cortex, premotor cortex, and parietal cortex. Here we show that, beyond the beneficial effects of VIM-DBS on motor execution, this form of invasive stimulation facilitates production of sequential finger movements that follow a fixed sequence but not when the sequence is selected at random. These results highlight the role of thalamo-cortical activity in motor learning.

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Voegtle, A., Terzic, L., Farahat, A., Hartong, N., Galazky, I., Hinrichs, H., Nasuto, S. J., de Oliveira Andrade, A., Knight, R. T., Ivry, R. B., Voges, J., Deliano, M., Buentjen, L., Sweeney-Reed, C. M.. 2023-09-22. Ventrointermediate thalamic stimulation improves motor learning in humans. https://doi.org/10.1101/2023.09.19.558378

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