Human brain state dynamics reflect individual neuro-phenotypes

Lee, K.; Ji, J. L.; Fonteneau, C.; Berkovitch, L.; Rahmati, M.; Pan, L.; Repovs, G.; Krystal, J. H.; Murray, J. D.; Anticevic, A.

doi:10.1101/2023.09.18.557763

bioRxiv · 10.1101/2023.09.18.557763

Human brain state dynamics reflect individual neuro-phenotypes

Lee, K.·Ji, J. L.·Fonteneau, C.·Berkovitch, L.·Rahmati, M.·Pan, L.·Repovs, G.·Krystal, J. H.·Murray, J. D.·Anticevic, A.

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Abstract

Neural activity and behavior vary within an individual (states) and between individuals (traits). However, the mapping of state-trait neural variation to behavior is not well understood. To address this gap, we quantify moment-to-moment changes in brain-wide co-activation patterns derived from resting-state functional magnetic resonance imaging. In healthy young adults, we identify reproducible spatio-temporal features of co-activation patterns at the single subject level. We demonstrate that a joint analysis of state-trait neural variations and feature reduction reveal general motifs of individual differences, en-compassing state-specific and general neural features that exhibit day-to-day variability. The principal neural variations co-vary with the principal variations of behavioral phenotypes, highlighting cognitive function, emotion regulation, alcohol and substance use. Person-specific probability of occupying a particular co-activation pattern is reproducible and associated with neural and behavioral features. This combined analysis of statetrait variations holds promise for developing reproducible neuroimaging markers of individual life functional outcome.

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Lee, K., Ji, J. L., Fonteneau, C., Berkovitch, L., Rahmati, M., Pan, L., Repovs, G., Krystal, J. H., Murray, J. D., Anticevic, A.. 2023-09-19. Human brain state dynamics reflect individual neuro-phenotypes. https://doi.org/10.1101/2023.09.18.557763

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