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bioRxiv · 10.1101/2023.09.02.556033

Sensitivity of BA.2.86 to prevailing neutralising antibody responses

Sheward, D. J.·Yang, Y.·Westerberg, M.·Öling, S.·Muschiol, S.·Sato, K.·Peacock, T. P.·Karlsson Hedestam, G. B.·Albert, J.·Murrell, B.
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Abstract

A new SARS-CoV-2 variant, designated BA.2.86, has recently emerged with over 30 spike mutations relative to its parental BA.2, raising questions about its degree of resistance to neutralising antibodies. Using a spike-pseudotyped virus model we characterise neutralisation of BA.2.86 by clinically relevant monoclonal antibodies and by two cohorts of serum sampled from Stockholm, including both a recent cohort, and one sampled prior to the arrival of XBB in Sweden.

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Sheward, D. J., Yang, Y., Westerberg, M., Öling, S., Muschiol, S., Sato, K., Peacock, T. P., Karlsson Hedestam, G. B., Albert, J., Murrell, B.. 2023-09-04. Sensitivity of BA.2.86 to prevailing neutralising antibody responses. https://doi.org/10.1101/2023.09.02.556033

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