Earliest observation of the tetracycline destructase tet(X3)

Grenier, F.; Levesque, S.; Rodrigue, S.; Haraoui, L.-P.

doi:10.1101/2023.08.29.555419

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bioRxiv · 10.1101/2023.08.29.555419

Earliest observation of the tetracycline destructase tet(X3)

Grenier, F.·Levesque, S.·Rodrigue, S.·Haraoui, L.-P.

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Abstract

Tigecycline is an antibiotic of last resort for infections with carbapenem-resistant Acinetobacter baumannii. Plasmids harboring variants of the tetracycline destructase tet(X) promote rising tigecycline resistance rates. We report the earliest observation of tet(X3) in a clinical strain predating tigecyclines commercialization, suggesting selective pressures other than tigecycline contributed to its emergence.

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Grenier, F., Levesque, S., Rodrigue, S., Haraoui, L.-P.. 2023-08-30. Earliest observation of the tetracycline destructase tet(X3). https://doi.org/10.1101/2023.08.29.555419

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