Cerebral perfusion alterations in temporal lobe epilepsy: Structural underpinnings and network disruptions

Ngo, A.; Royer, J.; Rodriguez-Cruces, R.; Xie, K.; DeKraker, J.; Auer, H.; Tavakol, S.; Lam, J.; Schrader, D.; Dudley, R. W. R.; Bernasconi, A.; Ladbon-Bernasconi, N.; Frauscher, B.; Lariviere, S.; Bernhardt, B. C.

doi:10.1101/2023.08.22.553552

bioRxiv · 10.1101/2023.08.22.553552

Cerebral perfusion alterations in temporal lobe epilepsy: Structural underpinnings and network disruptions

Ngo, A.·Royer, J.·Rodriguez-Cruces, R.·Xie, K.·DeKraker, J.·Auer, H.·Tavakol, S.·Lam, J.·Schrader, D.·Dudley, R. W. R.·Bernasconi, A.·Ladbon-Bernasconi, N.·Frauscher, B.·Lariviere, S.·Bernhardt, B. C.

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Abstract

AO_SCPLOWBSTRACTC_SCPLOWO_ST_ABSOO_SCPLOWBJECTIVEC_SCPLOWC_ST_ABSNeuroimaging has been the prevailing method to study brain networks in temporal lobe epilepsy (TLE), showing widespread alterations beyond the mesiotemporal lobe. Despite the critical role of the cerebrovascular system in maintaining whole-brain structure and function, changes in cerebral blood flow (CBF) remain incompletely understood in the disease. MO_SCPLOWETHODSC_SCPLOWWe studied 24 individuals with pharmaco-resistant TLE and 38 healthy adults using multimodal 3T magnetic resonance imaging. We compared regional CBF changes in patients relative to controls and related our perfusion findings to morphological and microstructural metrics. We further probed inter-regional vascular networks in TLE, using graph theoretical CBF covariance analysis. Finally, we assessed the effects of disease duration to study progressive changes. RO_SCPLOWESULTSC_SCPLOWCompared to controls, individuals with TLE showed widespread CBF reductions, predominantly in fronto-temporal regions, with 83% of patients showing more marked decreases ipsilateral than contralateral to the seizure focus. Parallel structural profiling and network-based models showed that cerebral hypoperfusion may be partly constrained by grey and white matter changes and topologically segregated from whole-brain perfusion networks. Negative effects of progressive disease duration further targeted regional CBF profiles in patients. Findings were confirmed in a subgroup of patients who remained seizure-free after surgery. IO_SCPLOWNTERPRETATIONC_SCPLOWOur multimodal findings provide insights into vascular contributions to TLE pathophysiology and highlight their clinical potential in seizure lateralization.

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Ngo, A., Royer, J., Rodriguez-Cruces, R., Xie, K., DeKraker, J., Auer, H., Tavakol, S., Lam, J., Schrader, D., Dudley, R. W. R., Bernasconi, A., Ladbon-Bernasconi, N., Frauscher, B., Lariviere, S., Bernhardt, B. C.. 2023-08-24. Cerebral perfusion alterations in temporal lobe epilepsy: Structural underpinnings and network disruptions. https://doi.org/10.1101/2023.08.22.553552

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