Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity

Moreno, A.; Manning, K.; Azeem, M. I.; Nooka, A. K.; Ellis, M.; Manalo, R. J.; Switchenko, J. M.; Wali, B.; Kaufman, J. L.; Hofmeister, C. C.; Joseph, N. S.; Lonial, S.; Dhodapkar, K. M.; Dhodapkar, M. V.; Suthar, M. S.

doi:10.1101/2023.08.17.553767

bioRxiv · 10.1101/2023.08.17.553767

Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity

Moreno, A.·Manning, K.·Azeem, M. I.·Nooka, A. K.·Ellis, M.·Manalo, R. J.·Switchenko, J. M.·Wali, B.·Kaufman, J. L.·Hofmeister, C. C.·Joseph, N. S.·Lonial, S.·Dhodapkar, K. M.·Dhodapkar, M. V.·Suthar, M. S.

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Abstract

We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.

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Moreno, A., Manning, K., Azeem, M. I., Nooka, A. K., Ellis, M., Manalo, R. J., Switchenko, J. M., Wali, B., Kaufman, J. L., Hofmeister, C. C., Joseph, N. S., Lonial, S., Dhodapkar, K. M., Dhodapkar, M. V., Suthar, M. S.. 2023-08-25. Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity. https://doi.org/10.1101/2023.08.17.553767

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