Familiarity-modulated synapses model visual cortical circuit novelty responses

Abstract

Since environments are constantly in flux, the brains ability to identify novel stimuli that fall outside its own internal representation of the world is crucial for an organisms survival. Within the mammalian neocortex, inhibitory microcircuits are proposed to regulate activity in an experience-dependent manner and different inhibitory neuron subtypes exhibit distinct novelty responses. Discerning the function of diverse neural circuits and their modulation by experience can be daunting unless one has a biologically plausible mechanism to detect and learn from novel experiences that is both understandable and flexible. Here we introduce a learning mechanism, familiarity modulated synapses (FMSs), through which a network response that encodes novelty emerges from unsupervised multiplicative synaptic modifications depending only on the presynaptic or both the pre- and postsynaptic activity. FMSs stand apart from other familiarity mechanisms in their simplicity: they operate under continual learning, do not require specialized architecture, and can distinguish novelty rapidly without requiring feedback. Implementing FMSs within an experimentally-constrained model of a visual cortical circuit, we demonstrate the generalizability of FMSs by reproducing three distinct novelty effects recently observed in experiments: absolute, contextual (or oddball), and omission novelty. Additionally, our model reproduces functional diversity within cell subpopulations, leading to experimentally testable predictions about connectivity and synaptic dynamics that can produce both population-level novelty responses and heterogeneous individual neuron signals. Altogether, our findings demonstrate how simple plasticity mechanisms within the cortical circuit structure can give rise to qualitatively distinct novelty responses. The flexibility of FMSs opens the door to computationally and theoretically investigating how distinct synapse modulations can lead to a variety of experience-dependent responses in a simple, understandable, and biologically plausible setup.