Germline mutation rate predicts cancer mortality across 37 vertebrate species

Kapsetaki, S. E.; Compton, Z. T.; Mellon, W.; Vincze, O.; Giraudeau, M. T.; Harrison, T.; Abegglen, L.; Boddy, A.; Maley, C. C.; Schiffman, J.

doi:10.1101/2023.08.13.553123

bioRxiv · 10.1101/2023.08.13.553123

Germline mutation rate predicts cancer mortality across 37 vertebrate species

Kapsetaki, S. E.·Compton, Z. T.·Mellon, W.·Vincze, O.·Giraudeau, M. T.·Harrison, T.·Abegglen, L.·Boddy, A.·Maley, C. C.·Schiffman, J.

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Abstract

The explanation for why some species are more susceptible to cancer than others remains an area of intense investigation. Cancer evolves in part through the accumulation of mutations and, therefore, we hypothesized that germline mutation rates would be associated with cancer prevalence and mortality across species. We collected previously published data on germline mutation rate and cancer mortality data for 37 vertebrate species. Germline mutation rate was positively correlated with cancer mortality (P = 0.008). Why animals with increased germline mutation rates die more from cancer remains an open question, however they may benefit from close monitoring for tumors due to hereditary cancer predisposition syndromes. Early diagnoses of cancer in these species may increase their chances of treatment and overall survival.

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Kapsetaki, S. E., Compton, Z. T., Mellon, W., Vincze, O., Giraudeau, M. T., Harrison, T., Abegglen, L., Boddy, A., Maley, C. C., Schiffman, J.. 2023-08-15. Germline mutation rate predicts cancer mortality across 37 vertebrate species. https://doi.org/10.1101/2023.08.13.553123

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