Functional and anatomical connectivity predict brain stimulation's mnemonic effects

Ezzyat, Y.; Kragel, J. E.; Solomon, E. A.; Lega, B. C.; Aronson, J. P.; Jobst, B. C.; Gross, R. E.; Sperling, M. R.; Worrell, G. A.; Sheth, S. A.; Wanda, P. A.; Rizzuto, D. S.; Kahana, M. J.

doi:10.1101/2023.07.27.550851

bioRxiv · 10.1101/2023.07.27.550851

Functional and anatomical connectivity predict brain stimulation's mnemonic effects

Ezzyat, Y.·Kragel, J. E.·Solomon, E. A.·Lega, B. C.·Aronson, J. P.·Jobst, B. C.·Gross, R. E.·Sperling, M. R.·Worrell, G. A.·Sheth, S. A.·Wanda, P. A.·Rizzuto, D. S.·Kahana, M. J.

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Abstract

Closed-loop direct brain stimulation is a promising tool for modulating neural activity and behavior. However, it remains unclear how to optimally target stimulation to modulate brain activity in particular brain networks that underlie particular cognitive functions. Here, we test the hypothesis that stimulations behavioral and physiological effects depend on the stimulation targets anatomical and functional network properties. We delivered closed-loop stimulation as 47 neurosurgical patients studied and recalled word lists. Multivariate classifiers, trained to predict momentary lapses in memory function, triggered stimulation of the lateral temporal cortex (LTC) during the study phase of the task. We found that LTC stimulation specifically improved memory when delivered to targets near white matter pathways. Memory improvement was largest for targets near white matter that also showed high functional connectivity to the brains memory network. These targets also reduced low-frequency activity in this network, an established marker of successful memory encoding. These data reveal how anatomical and functional networks mediate stimulations behavioral and physiological effects, provide further evidence that closed-loop LTC stimulation can improve episodic memory, and suggest a method for optimizing neuromodulation through improved stimulation targeting.

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Ezzyat, Y., Kragel, J. E., Solomon, E. A., Lega, B. C., Aronson, J. P., Jobst, B. C., Gross, R. E., Sperling, M. R., Worrell, G. A., Sheth, S. A., Wanda, P. A., Rizzuto, D. S., Kahana, M. J.. 2023-07-29. Functional and anatomical connectivity predict brain stimulation's mnemonic effects. https://doi.org/10.1101/2023.07.27.550851

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