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bioRxiv · 10.1101/2023.06.24.546170

Synapsin E-domain is essential for α-synuclein function

Stavsky, A.·Parra-Rivas, L. A.·Tal, S.·Madhivanan, K.·Roy, S.·Gitler, D.
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Abstract

The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here we identify the synapsin E-domain as an essential functional binding-partner of -synuclein (-syn). Synapsin E-domain allows -syn functionality, binds to -syn, and is necessary and sufficient for enabling effects of -syn at the synapse. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters.

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Stavsky, A., Parra-Rivas, L. A., Tal, S., Madhivanan, K., Roy, S., Gitler, D.. 2023-06-26. Synapsin E-domain is essential for α-synuclein function. https://doi.org/10.1101/2023.06.24.546170

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