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bioRxiv · 10.1101/2023.06.14.545010

Functional Sexual Dimorphism in Human Nociceptors

Stratton, H. J.·Dolatyari, M.·Dumaire, N.·Moutal, A.·Ghetti, A.·Cotta, T.·Mitchell, S.·Yue, X.·Navratilova, E.·Porreca, F.
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Abstract

The recent demonstration of differences in transcript expression in human post-mortem sensory neurons suggests the possibility of sexually dimorphic pain mechanisms. To date, however, the concept of "male" and "female" nociceptors has not been demonstrated at a functional level. We now report sensitization of female, but not male, human nociceptors by prolactin revealing a female-selective mechanism that can be exploited to improve the treatment of pain in women.

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Stratton, H. J., Dolatyari, M., Dumaire, N., Moutal, A., Ghetti, A., Cotta, T., Mitchell, S., Yue, X., Navratilova, E., Porreca, F.. 2023-06-15. Functional Sexual Dimorphism in Human Nociceptors. https://doi.org/10.1101/2023.06.14.545010

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