A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

Chang, H.; Feng, S.; Tang, X.; Wang, Z.; Su, W.; Han, S.; Li, G.; Hu, B.; Jing, S.; Wang, B.; Xiang, C.; Xing, Y.; Wang, Y.; Lu, J.; He, h.

doi:10.1101/2023.06.05.543675

bioRxiv · 10.1101/2023.06.05.543675

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

Chang, H.·Feng, S.·Tang, X.·Wang, Z.·Su, W.·Han, S.·Li, G.·Hu, B.·Jing, S.·Wang, B.·Xiang, C.·Xing, Y.·Wang, Y.·Lu, J.·He, h.

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Abstract

PPMV-1, an antigenic variant of APMV-1, associated with specific pigeon host species. However, its evolutionary strategy and underlying drivers of host specificity remain unknown. In this study, we collect the outbreak data on a global scale to investigate its evolutionary dynamics, and provide an evidence-supported analysis the host shift of PPMV-1 from chickens to pigeons, and this shift is driven by the P protein. Our data indicated that the viruses in the United States and China have undergone convergent evolution. We find that three mutations of P protein, especially R163G, can significantly affect the adaptation of APMV-1 in pigeons. Mechanistically, sensor LSm14A inhibits the replication APMV-1 in DF-1 cells, and R163G substitutionon P protein increase LSm14A degradation. We propose the host shift drive the evolution of PPMV-1 and the underlying mechanism, offering new insights into the adaptive evolutionary process of the virus.

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Chang, H., Feng, S., Tang, X., Wang, Z., Su, W., Han, S., Li, G., Hu, B., Jing, S., Wang, B., Xiang, C., Xing, Y., Wang, Y., Lu, J., He, h.. 2023-06-05. A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution. https://doi.org/10.1101/2023.06.05.543675

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