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bioRxiv · 10.1101/2023.05.24.542127

A pancreatic cancer mouse model with human immunity

Miyamura, N.·Suzuki, K.·Friedman, R. A.·Floratos, A.·Kunisada, Y.·Masuda, K.·Lowy, A. M.·Tsuji, M.·Sugahara, K. N.
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a tumor immune microenvironment (TIME) that promotes resistance to immunotherapy. A preclinical model system that facilitates studies of the TIME and its impact on the responsiveness of human PDAC to immunotherapies remains an unmet need. We report a novel mouse model, which develops metastatic human PDAC that becomes infiltrated by human immune cells recapitulating the TIME of human PDAC. The model may serve as a versatile platform to study the nature of human PDAC TIME and its response to various treatments.

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Miyamura, N., Suzuki, K., Friedman, R. A., Floratos, A., Kunisada, Y., Masuda, K., Lowy, A. M., Tsuji, M., Sugahara, K. N.. 2023-05-24. A pancreatic cancer mouse model with human immunity. https://doi.org/10.1101/2023.05.24.542127

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