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bioRxiv · 10.1101/2023.05.20.541597

Do cortical co-ripples bind lines, letters, words, meanings, strategy and action in reading?

Garrett, J. C.·Verzhbinsky, I. A.·Kaestner, E.·Carlson, C.·Doyle, W. K.·Devinsky, O.·Thesen, T.·Halgren, E.
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Abstract

Whether high-frequency phase-locked oscillations facilitate integration ( binding) of information across widespread cortical areas is controversial. Here we show with intracranial EEG that cortico-cortical co-ripples ([~]100ms long [~]90Hz oscillations) increase during reading and semantic decisions, at the times and co-locations when and where binding should occur. Fusiform wordform areas co-ripple with virtually all language areas, maximally from 200-400ms post-word-onset. Semantically-specified target words evoke strong co-rippling between wordform, semantic, executive and response areas from 400-800ms, with increased co-rippling between semantic, executive and response areas prior to correct responses. Co-ripples were phase-locked at zero-lag over long distances (>12cm), especially when many areas were co-rippling. General co-activation, indexed by non-oscillatory high gamma, was mainly confined to early latencies in fusiform and earlier visual areas, preceding co-ripples. These findings suggest that widespread synchronous co-ripples may assist the integration of multiple cortical areas for sustained periods during cognition. One Sentence SummaryWidespread visual, wordform, semantic, executive and response areas phase-lock at 90Hz during integrative semantic processing.

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Garrett, J. C., Verzhbinsky, I. A., Kaestner, E., Carlson, C., Doyle, W. K., Devinsky, O., Thesen, T., Halgren, E.. 2023-05-22. Do cortical co-ripples bind lines, letters, words, meanings, strategy and action in reading?. https://doi.org/10.1101/2023.05.20.541597

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